First DNA molecule made from (almost) entirely Artificial Parts

Bit late to the party on this one, but it’s definitely worth noting.

Chemists at a University in Japan are reporting the first artificially synthesised DNA molecule.

The researchers used high-tech DNA synthesis equipment to stitch together four entirely new, artificial bases inside the sugar-based framework of a DNA molecule. This resulted in unusually stable, double-stranded structures resembling natural DNA.

Like natural DNA, the new structures were right-handed and some easily formed triple-stranded structures. The unique chemistry of these structures and their high stability offer unprecedented possibilities for developing new biotech materials and applications, the researchers say.

More?

Doi et al. Artificial DNA Made Exclusively of Nonnatural C-Nucleosides with Four Types of Nonnatural Bases. Journal of the American Chemical Society, 2008; 130 (27): 8762 DOI: 10.1021/ja801058h

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